{"id":1651,"date":"2019-07-08T17:36:00","date_gmt":"2019-07-08T20:36:00","guid":{"rendered":"https:\/\/sites.uel.br\/estomatologia\/?p=1651"},"modified":"2025-02-13T11:26:06","modified_gmt":"2025-02-13T14:26:06","slug":"descoberta-de-carcinoma-de-celulas-escamosas-em-lesao-previamente-diagnosticada-como-liquen-plano-oral-malignizacao-ou-erro-de-diagnostico-inicial","status":"publish","type":"post","link":"https:\/\/sites.uel.br\/estomatologia\/publicacoes\/artigos-cientificos\/2019\/07\/08\/descoberta-de-carcinoma-de-celulas-escamosas-em-lesao-previamente-diagnosticada-como-liquen-plano-oral-malignizacao-ou-erro-de-diagnostico-inicial\/","title":{"rendered":"Descoberta de Carcinoma de C\u00e9lulas Escamosas em Les\u00e3o Previamente Diagnosticada como L\u00edquen Plano Oral: Maligniza\u00e7\u00e3o ou Erro de Diagn\u00f3stico Inicial?"},"content":{"rendered":"\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p style=\"font-size:16px\"><strong>DOI: <a href=\"https:\/\/doi.org\/10.21270\/archi.v8i4.3296\">https:\/\/doi.org\/10.21270\/archi.v8i4.3296<\/a><br>Palavras-chave:&nbsp;Diagn\u00f3stico, l\u00edquen plano, carcinoma de c\u00e9lulas escamosas<br>Edi\u00e7\u00e3o: <a href=\"https:\/\/archhealthinvestigation.com.br\/ArcHI\/issue\/view\/105\" data-type=\"link\" data-id=\"https:\/\/archhealthinvestigation.com.br\/ArcHI\/issue\/view\/105\">Vol. 8, N. 4 (2019)<\/a><\/strong><\/p>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-buttons is-horizontal is-content-justification-center is-nowrap is-layout-flex wp-container-core-buttons-is-layout-980e04e1 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-custom-font-size is-style-fill\" style=\"font-size:15px\"><a class=\"wp-block-button__link has-cinza-claro-color has-text-color has-background has-link-color wp-element-button\" href=\"https:\/\/sites.uel.br\/estomatologia\/wp-content\/uploads\/2025\/02\/descoberta-de-carcinoma-de-celulas-escamosas-em-lesao-previamente-diagnosticada-como-liquen-plano-oral-malignizacao-ou-erro-de-diagnostico-inicial-1.pdf\" style=\"border-radius:7px;background-color:#00753b\">Acesse PDF<\/a><\/div>\n<\/div>\n\n\n\n<div style=\"height:35px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-color has-link-color wp-elements-1f152522925277e346a9e57648153928\" style=\"color:#004422;font-size:20px\"><strong>Resumo<\/strong><\/p>\n\n\n\n<div style=\"height:3px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-medium-font-size\">O L\u00edquen Plano Oral (LPO) \u00e9 uma doen\u00e7a cr\u00f4nica imunologicamente mediada com potencial de maligniza\u00e7\u00e3o incerto. O objetivo desse artigo \u00e9 relatar um caso de Carcinoma de C\u00e9lulas Escamosas (CCE) diagnosticado em paciente com diagn\u00f3stico pr\u00e9vio de LPO. Paciente do sexo feminino, 69 anos, foi atendida durante uma campanha de diagn\u00f3stico precoce de c\u00e2ncer de boca realizada na cidade de Londrina\/PR, sendo detectada uma les\u00e3o eritropl\u00e1sica em l\u00edngua e encaminhada para uma melhor avalia\u00e7\u00e3o. Na anamnese a paciente relatou que h\u00e1 2 anos atr\u00e1s foi diagnosticada com LPO atrav\u00e9s de bi\u00f3psia em l\u00edngua, n\u00e3o sendo proposto nenhum tratamento. Ao exame f\u00edsico, observamos uma mancha eritematosa em borda lateral de l\u00edngua do lado esquerdo, n\u00e3o apresentando nenhuma outra les\u00e3o na cavidade oral. Com a hip\u00f3tese diagn\u00f3stica de eritroplasia, foi requisitada a l\u00e2mina da bi\u00f3psia anterior para an\u00e1lise, que revelou caracter\u00edsticas microsc\u00f3picas incompat\u00edveis com o diagn\u00f3stico de LPO. Optamos ent\u00e3o por realizar uma nova bi\u00f3psia e a an\u00e1lise histopatol\u00f3gica revelou ilhas de c\u00e9lulas epiteliais malignas invadindo o tecido conjuntivo, estabelecendo o diagn\u00f3stico de CCE. A paciente foi encaminhada para tratamento, sendo realizada glossectomia parcial. Em acompanhamento de 6 meses a paciente encontra-se bem e sem sinais de recidiva. A transforma\u00e7\u00e3o maligna do LPO ainda \u00e9 discutida na literatura e muitos casos relatados podem se tratar de erro no diagn\u00f3stico inicial, como no caso apresentado. O erro de diagn\u00f3stico pode levar a morbidades importantes e comprometer o progn\u00f3stico do caso.<\/p>\n\n\n\n<div style=\"height:1px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-cinza-claro-color has-alpha-channel-opacity has-cinza-claro-background-color has-background is-style-wide\" \/>\n\n\n\n<div style=\"height:22px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-color has-link-color wp-elements-922ac6c1cb1423a769287eb13e3c3265\" style=\"color:#004422;font-size:20px\"><strong>Autores<\/strong><\/p>\n\n\n\n<div style=\"height:3px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p style=\"font-size:16px\"><strong><strong><strong>Adriana Caroline Leite<\/strong><\/strong><\/strong><br>Aluna de Gradua\u00e7\u00e3o &#8211; Universidade Estadual de Londrina<br><br><strong><strong><strong>Nathalia Torres Assay<\/strong><\/strong><\/strong><br>Aluna de Gradua\u00e7\u00e3o &#8211; Universidade Estadual de Londrina<br><br><strong>Fabio Augusto Ito<\/strong><br>Docente da \u00c1rea de Diagn\u00f3stico Oral &#8211; Universidade Estadual de Londrina<br><br><strong>Heliton Gustavo de Lima<\/strong><br>Docente da \u00c1rea de Diagn\u00f3stico Oral &#8211; Universidade Estadual de Londrina<br><br><strong>Ademar Takahama Junior*<\/strong><br>Docente da \u00c1rea de Diagn\u00f3stico Oral &#8211; Universidade Estadual de Londrina<\/p>\n\n\n\n<div style=\"height:1px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-cinza-claro-color has-alpha-channel-opacity has-cinza-claro-background-color has-background is-style-wide\" \/>\n\n\n\n<div style=\"height:22px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-color has-link-color wp-elements-ebc8fb7da3a22d315daf310df1cc59c6\" style=\"color:#004422;font-size:20px\"><strong>Refer\u00eancias<\/strong><\/p>\n\n\n\n<div style=\"height:3px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p style=\"font-size:16px\">Giuliani M, Troiano G, Cordaro M, Corsalini M, Gioco G, Lo Muzio L et al. Rate of malignant transformation of Oral Lichen Planus: a systematic review. Oral Dis. 2019; 25(3):693-709.<br><br>Bardellini E, Amadori F, Flocchini P, Bonadeo S, Majorana A. Clinicopathological features and malignant transformation of oral lichen planus: a 12-years retrospective study. Acta Odontologica Scandinavica 2013;71(3\/4):834-40.<br><br>Eisen D. The clinical features, malignant potential, and systemic associations of oral lichen planus: a study of 723 patients. J Am Acad Dermatol. 2002;46(2):207-14.<br><br>Farhi D, Dupin N. Pathophysiology, etiologic factors, and clinical management of oral lichen planus, part I: facts and controversies. Clin Dermatol. 2010;28(1):100-8.<br><br>Roopashree MR, Gondhalekar RV, Shashikanth MC, George J, Thippeswamy SH, Shukla A. Pathogenesis of oral lichen planus &#8211; a review. J Oral Pathol Med. 2010;39(10):729-34.<br><br>van der Meij EH, van der Waal I. Lack of clinicopathologic correlation in the diagnosis of oral lichen planus based on the presently available diagnostic criteria and suggestions for modifications. J Oral Pathol Med. 2003;32(9):507-12.<br><br>Kramer IR, Lucas RB, Pindborg JJ, Sobin LH. Definition of leukoplakia and related lesions: an aid to studies on oral precancer. Oral Surg Oral Med Oral Pathol. 1978;46(4):518-39.<br><br>Aghbari SMH, Abushouk AI, Attia A, Elmaraezy A, Menshawy A, Ahmed MS et al. Malignant transformation of oral lichen planus and oral lichenoid lesions: a meta-analysis of 20095 patient data. Oral Oncology. 2017;68:92-102.<br><br>Eisenberg E. Oral lichen planus:a benign lesion. J Oral Maxillofac Surg. 2000;58(11):1278-85.<br><br>Alrashdan MS, Cirillo N, McCullough M. Oral lichen planus: a literature review and update. Arch Dermatol Res. 2016;308(8):539-51.<br><br>Lodi G, Scully C, Carrozzo M, Griffiths M, Sugerman PB, Thongprasom K. Current controversies in oral lichen planus: report of an international consensus meeting. Part 2. Clinical management and malignant transformation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;100(2):164-78.<br><br>Sousa FACG, Paradella TC, Brand\u00e3o AAH, Rosa LEB. L\u00edquen plano bucal versus displasia epitelial: dificuldades diagn\u00f3sticas. Braz J Otorhinolaryngol. 2009;75(5):716-20.<br><br>Rode M, Kogoj-Rode M. Malignant potential of the reticular form of oral lichen planus over a 25-year observation period in 55 patients from Slovenia. J Oral Sci. 2002;44(2):109-11.<br><br>Van der Meij EH, Mast H, Van der Waal I. The possible premalignant character of oral lichen planus and oral lichenoid lesions: a prospective five-year followup study of 192 patients. Oral Oncol. 2007;43(8):742-48.<br><br>Oliveira Alves MG, Almeida JD, Balducci I, Guimar\u00e3es Cabral LA. Oral lichen planus: a retrospective study of 110 Brazilian patients. BMC Res Notes. 2010;3:157.<br><br>Radochov\u00e1 V, Dr\u02c7\u00edzhal I, Slez\u00e1k R. A retrospective study of 171 patients with oral lichen planus in the East Bohemia-Czech Republic\u2013single center experience. J Clin Exp Dent. 2014;6(5):e556-61.<br><br>Fitzpatrick S, Hirsch S, Gordon S. The malignant transformation of oral lichen planus and oral lichenoid lesions: a systematic review. J Am Dent Assoc. 2014;145(1):45-56.<br><br>Bermejo-Fenoll A, S\u00e1nchez-Siles M, L\u00f3pez-Jornet P, Camacho-Alonso F, Salazar-S\u00e1nchez N. A retrospective clinicopathological study of 550 patients with oral lichen planus in south-eastern Spain. J Oral Pathol Med. 2010;39(6):491-96.<br><br>Chaiyarit P, Ma N, Hiraku Y, Pinlaor S, Yongvanit P, Jintakanon D et al. Nitrative and oxidative DNA damage in oral lichen planus in relation to human oral carcinogenesis. Cancer Sci. 2005;96:553-59.<br><br>Georgakopoulou EA, Achtari MD, Achtaris M, Foukas PG, Kotsinas A. Oral lichen planus as a preneoplastic inflammatory model. J Biomed Biotechnol. 2012;2012:759626.<br><br>Accurso BT, Warner BM, Knobloch TJ, Weghorst CM, Shumway BS, Allen CM et al. Allelic imbalance in oral lichen planus and assessment of its classification as a premalignant condition. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;112(3):359-66.<\/p>\n\n\n\n<div style=\"height:1px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-cinza-claro-color has-alpha-channel-opacity has-cinza-claro-background-color has-background is-style-wide\" \/>\n","protected":false},"excerpt":{"rendered":"<p>O objetivo desse artigo \u00e9 relatar um caso de Carcinoma de C\u00e9lulas Escamosas (CCE) diagnosticado em paciente com diagn\u00f3stico pr\u00e9vio de LPO. Paciente do sexo feminino, 69 anos, foi atendida durante uma campanha de diagn\u00f3stico precoce de c\u00e2ncer de boca realizada na cidade de Londrina\/PR, sendo detectada uma les\u00e3o eritropl\u00e1sica em l\u00edngua e encaminhada para uma melhor avalia\u00e7\u00e3o.<\/p>\n","protected":false},"author":9,"featured_media":1673,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[32],"tags":[],"class_list":["post-1651","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-artigos-cientificos"],"acf":[],"_links":{"self":[{"href":"https:\/\/sites.uel.br\/estomatologia\/wp-json\/wp\/v2\/posts\/1651","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.uel.br\/estomatologia\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.uel.br\/estomatologia\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.uel.br\/estomatologia\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.uel.br\/estomatologia\/wp-json\/wp\/v2\/comments?post=1651"}],"version-history":[{"count":10,"href":"https:\/\/sites.uel.br\/estomatologia\/wp-json\/wp\/v2\/posts\/1651\/revisions"}],"predecessor-version":[{"id":1998,"href":"https:\/\/sites.uel.br\/estomatologia\/wp-json\/wp\/v2\/posts\/1651\/revisions\/1998"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sites.uel.br\/estomatologia\/wp-json\/wp\/v2\/media\/1673"}],"wp:attachment":[{"href":"https:\/\/sites.uel.br\/estomatologia\/wp-json\/wp\/v2\/media?parent=1651"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.uel.br\/estomatologia\/wp-json\/wp\/v2\/categories?post=1651"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.uel.br\/estomatologia\/wp-json\/wp\/v2\/tags?post=1651"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}